Chromatography Standards
Medchemexpress LLC Taprenepag isopropyl | 1005549-94-9 | 99.0% | 520.60 | 1 ML
Taprenepag isopropyl is a highly selective EP2 receptor agonist. It reduces intraocular pressure (IOP) in the right (dosed) eye in a dose-dependent manner in cynomolgus monkeys. In a high-dose group (0.75 mg/day), IOP was reduced to less than 4 mm Hg on Days 22 and 29. No clinical signs or changes in body weight were observed with any dose, and no ocular findings occurred in the low-dose group (0.75 mg/day).
- Highly selective EP2 receptor agonist.
- Reduces intraocular pressure (IOP) in a dose-dependent manner.
- Achieved IOP reduction to less than 4 mm Hg in high-dose group.
- No clinical signs or changes in body weight observed.
- No ocular findings occurred in the low-dose group.
- Target: EP2.
Medchemexpress LLC Naftifine (hydrochloride) | 65473-14-5 | 99.7% | 1 ML
Naftifine hydrochloride is an antibiotic with antifungal activity against dermatophytes, aspergilli, *Sporothrix schenckii*, and yeasts of the genus *Candida*. It is utilized for research into the inhibition of superficial dermatomycoses.
- Antibiotic with antifungal activity
- Effective against dermatophytes, aspergilli, *Sporothrix schenckii*, and *Candida* species
- Utilized for research into inhibition of superficial dermatomycoses
- Exhibits spectrum of activity with minimal inhibitory concentrations (MICs) against various fungi
- For research use only
Apexbio Technology LLC Dipyridamole 58-32-2 10mM (in 1mL DMSO)
Dipyridamole (CAS 58-32-2) is an orally bioactive phosphodiesterase (PDE) inhibitor that acts primarily by inhibiting the cellular uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells This mechanism elevates extracellular adenosine levels subsequently modulating adenosine-dependent pathways involved in platelet function vasodilation and coagulation processes Dipyridamole exhibits antiplatelet properties and is commonly used in research related to secondary stroke prevention Additionally it has demonstrated the ability to induce apoptosis in certain tumor cell lines highlighting potential applications in oncology research
Medchemexpress LLC Dicloxacillin (Sodium hydrate) | 13412-64-1 | 98.9% | 1 ML
Dicloxacillin (Sodium hydrate) is a chemical compound with CAS Number 13412-64-1, molecular formula C19H18Cl2N3NaO6S, and molecular weight 510.32. It appears as a white to off-white solid with a purity of 98.94% (LCMS). This product is intended for laboratory chemical use and research purposes only, and is stable under recommended storage conditions.
- Appears as a white to off-white solid
- Has a purity of 98.94% (LCMS)
- For research use only
- Stable under recommended storage conditions
- Store at 4°C, sealed, away from moisture
- When in solvent, store at -80°C for 6 months or -20°C for 1 month
Apexbio Technology LLC Ciprofloxacin (hydrochloride)(Synonyms: Cipro, Ciprofloxacin HCl, Ciprofloxacine hydrochloride, Ciprofloxacin hydrochloride monohydrate), 5g, CAS: 93107-08-5.
Ciprofloxacin (hydrochloride) (CAS 93107-08-5) is a fluoroquinolone antibiotic targeting bacterial DNA gyrase and topoisomerase IV enzymes essential for bacterial DNA replication and supercoiling By inhibiting these enzymes ciprofloxacin prevents bacterial chromosome replication and proliferation It also displays immunomodulatory activity evidenced by reduced serum pro-inflammatory cytokines (IL-6 KC) and decreased apoptosis and autophagy in radiation-induced injury mouse models Ciprofloxacin is FDA-approved for treating inhalational anthrax exposure significantly enhancing survival in rhesus monkeys infected with aerosolized B anthracis
Cayman Chemical Capecitabine, Purity: ≥98%, CAS: 154361-50-9, 5 g
A prodrug of 5-fluorouracil; cytotoxic only at high concentrations in Scaber, SIHA, and MKN45 cells (IC50s = 97, 578, and 994 µM, respectively); inactive in a variety of cancer cell lines, including COLO205, HCT116, and MCF-7 cells (IC50s = >1,000 µM)
Medchemexpress LLC Ganoderic acid C2 | 103773-62-2 | 518.68 | 1 ML
Ganoderic acid C2 is a bioactive triterpenoid found in *Ganoderma lucidum*. It possesses potential anti-tumor bioactivity, antihistamine, anti-aging, and cytotoxic effects. It is an inhibitor for aldose reductase with an IC50 of 43.8 μM.
- Purity: 99.72%
- Bioactive triterpenoid found in *Ganoderma lucidum*
- Potential activities include anti-tumor, antihistamine, anti-aging, and cytotoxic effects
- Aldose reductase inhibitor with an IC50 of 43.8 μM
- Appearance: solid, white to off-white
- Immunomodulatory activity exhibited in Cyclophosphamide-induced immunosuppression mouse models
Medchemexpress LLC Benzarone | 1477-19-6 | 99.7% | 266.29 | 500 MG
Benzarone is an oral inhibitor of human urate transporter 1 (hURAT1) with an IC50 value of 2.8 μM, and it also functions as an uncoupler of oxidative phosphorylation. This compound has the potential to cause liver damage and can promote cell apoptosis and necrosis. It is utilized to reduce serum uric acid levels and for research related to vascular diseases.
- Oral inhibitor of human urate transporter 1 (hURAT1).
- Functions as an uncoupler of oxidative phosphorylation.
- Used to lower serum uric acid levels.
- Useful for research in vascular diseases.
- May cause liver damage and promote cell apoptosis and necrosis.
Medchemexpress LLC D-Glucitol, 1,4:3,6-dianhydro-, 2,5-dinitrate | 87-33-2 | 99.89% | 25 MG
Isosorbide dinitrate (ISDN) is a Nitric Oxide (NO) donor that helps prevent left ventricular (LV) remodeling and degradation of cardiac function following myocardial infarction (MI).
- Synonyms: ISDN
- CAS No.: 87-33-2
- Purity: 99.89%
- Molecular weight: 236.14
- Formula: C6H8N2O8
- Appearance: Solid
- Color: White to off-white
- Handling: For research use only. Not sold to patients.
- Storage: 4°C, protect from light. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light).
- Solubility: In DMSO: 100 mg/mL (423.48 mM); requires ultrasonic and newly opened hygroscopic DMSO.
Medchemexpress LLC Oxytetracycline hydrochloride | 2058-46-0 | MFCD00135815 | 98.92% | 1 ML
Oxytetracycline hydrochloride is an antibiotic belonging to the tetracycline class. It potently inhibits Gram-negative and Gram-positive bacteria. It acts as a protein synthesis inhibitor, preventing the binding of aminoacyl-tRNA to the m-ribosomal RNA complex. It also possesses anti-HSV-1 activity.
- Potently inhibits Gram-negative and Gram-positive bacteria
- Acts as a protein synthesis inhibitor
- Exhibits anti-HSV-1 activity
Medchemexpress LLC Sarafloxacin hydrochloride | 91296-87-6 | 98.13% | 100 MG
Sarafloxacin hydrochloride is a quinolone antibiotic agent registered for use against poultry diseases. It has been shown to be effective in treating channel catfish infected with *E. ictaluri*.
- Quinolone antibiotic agent
- Registered for use against poultry diseases
- Efficacious in treating channel catfish infected with *E. ictaluri*
- Inhibitory level is strain dependent for tested bacteria
Medchemexpress LLC Tizanidine-d4 | 1188331-19-2 | 99.9% | 1 MG
Tizanidine-d4 is a deuterium labeled version of Tizanidine, a skeletal muscle relaxant and central α2-adrenoceptor agonist. It works by inhibiting the release of excitatory amino acids from spinal cord interneurons, reducing muscle spasticity. Tizanidine-d4 also shows anti-injury activity, can inhibit GI transport, and may inhibit proliferation, migration, and invasion of lung cancer cells by inducing cell apoptosis through specific signaling pathways. It is used to treat spasticity from conditions like multiple sclerosis, stroke, and spinal cord injury.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Exhibits anti-injury activity
- Can inhibit gastrointestinal (GI) transport
- May inhibit proliferation, migration, and invasion of lung cancer cells
- Induces cell apoptosis by upregulating Nischarin and inhibiting AKT and Wnt3a/β-catenin signaling pathways
Medchemexpress LLC Fluticasone propionate | 80474-14-2 | 99.93% | 500 MG
Fluticasone propionate is a potent topical anti-inflammatory corticosteroid. It acts as a selective glucocorticoid receptor agonist, exhibiting an absolute affinity (KD) of 0.5 nM. The product shows minimal to no activity at other steroid receptors and also possesses anti-viral activity.
- Potent topical anti-inflammatory corticosteroid
- Selective glucocorticoid receptor agonist
- Absolute affinity (KD) of 0.5 nM
- Minimal to no activity at other steroid receptors
- Possesses anti-viral activity
Medchemexpress LLC Methylprednisolone | 83-43-2 | 99.78% | 5 G
Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. It has been shown to improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels. It is commonly used for anti-inflammatory purposes and in the study of various inflammatory conditions.
- Synthetic corticosteroid with anti-inflammatory and immunomodulating properties
- Can improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels
- Commonly used for anti-inflammatory purposes
- Can be used in the study of bronchial inflammation or acute bronchitis caused by arthritis and various respiratory diseases
- Can improve neurological recovery in acute spinal cord injury
- Triggers osteoblast death through multiple pathways, inducing femoral head necrosis
Medchemexpress LLC Glipizide (Standard) | 29094-61-9 | 99.7% | 100 MG
Glipizide (Standard) is an analytical standard intended for research and analytical applications. This potent, orally active sulfonylurea class anti-diabetic agent is used for type 2 diabetes mellitus research, acting by partially blocking ATP-sensitive potassium channels among β cells of pancreatic islets of Langerhans.
- Analytical standard for research and analytical applications
- Potent, orally active sulfonylurea class anti-diabetic agent
- Used for type 2 diabetes mellitus research
- Acts by partially blocking ATP-sensitive potassium (KATP) channels
- Reference standard supplied assay
- Commonly used in qualitative, quantitative, and methodological research experiments
- Suitable for HPLC, GC, and MS